• Compound Management

    Secure compound aggregation & storage, & rapid delivery in screen-ready format, to your in-house labs and CRO partners.

Introduction

Our compound management services allow our customers to both save costs and accelerate their drug discovery.  Operating since 2005, our €20 million facility stores and manages customer libraries ranging in size from a few thousand to a few hundred thousand compounds in both liquid and solid formats.

We constantly receive and aggregate new compounds from our customers and their chemistry CRO partners, and ship in the assay-ready format of choice to their screening laboratories.

BioAscent can support some or all of your key compound management activities including aggregation, storage, weighing, dissolution, plating, LC-MS analysis and distribution. We provide both standalone activities on a fee-for service basis, as well as fully integrated compound management services. Our transparent activity pricing makes it easy to calculate cost savings.

Our Customers

We have over 70 customers, ranging from big pharma to virtual biotechs, managing libraries ranging in size from a few thousand to a few hundred thousand compounds.

Our Customers

We have over 70 customers, ranging from big pharma to virtual biotechs and charity and academic consortia, and we currently hold and manage over 1 million compounds for them.

Our expertise in cherry picking, reformatting, shipping and data management have allowed us to deliver over 80,000 screening plates globally to our customers and their partner testing laboratories since 2013.

Our customers include Medivir, Merz, Pierre Fabre, Pivot Park Screening Centre and many others. Via the European Lead Factory we also provide compound management for collections from Bayer, Janssen, Lundbeck, Merck KgaA, Sanofi & UCB.

The Team

The BioAscent compound management team is led by Dr Sylviane Boucharens. A drug discovery and compound management expert with over 20 years of pharmaceutical industry experience, Sylviane led the global compound repository team and the in vitro screening team at the Merck Sharpe & Dohme / Schering Plough / Organon site in Newhouse, Scotland at which BioAscent is now based.

Sylviane is supported by a team of experts in compound management, data management and logistics working in state-of-the-art facilities originally commissioned to manage Merck Sharpe and Dohme’s global collection.

Sylvia

Sylviane Boucharens

Chief Operating Officer and Co-founder

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Services

We partner with you to manage some or all of your compound management, receipt, storage, formatting and distribution needs. We support all stages of the drug discovery process from screening and hit identification through to lead optimization and candidate selection.

A dedicated account manager works with you and your R&D partners, receiving new compounds from your chemistry providers, and providing assay ready plates on demand, all on a transparent activity-price basis.

Our data management expertise allows our customers to search and order from their collections directly.

 

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Services

We partner with you to manage some or all of your compound management, receipt, storage, formatting and distribution needs. We support all stages of the drug discovery process from screening and hit identification through to lead optimization and candidate selection.

A dedicated account manager works with you and your R&D partners, receiving new compounds from your chemistry providers, and providing assay ready plates on demand, all on a transparent activity-price basis.

Our data management expertise allows our customers to search and order from their collections directly.

Our services include:

  • Aggregation, Inventory Consolidation & Management
  • Compound Procurement, via preferred partners
  • Storage of both solid & liquid samples, in multiple storage formats at different temperatures
  • Compound Weighing
  • Compound Dissolution
  • Automated Reformatting & Plating within controlled, low humidity environment (96, 384 & 1536-well plates)
  • Acoustic Dispensing
  • Automated Tube Picking (96 & 384-well tubes) within controlled -20°C environment
  • Quality Control (LC-MS Analysis)
  • Compound Shipping & Logistics to in-house & partner testing laboratories
  • Online Inventory & Ordering
  • Fully auditable order fulfilment via Titian Software’s Mosaic, including connectivity with your existing informatics systems
  • Compound Collection Backup & Disaster Recovery

Our Facility

Operating since 2005, our €20 million facility stores and manages customer libraries ranging in size from a few thousand to a few hundred thousand compounds in both liquid and solid formats.

Our Facility

Our facility offers a compound storage and logistics platform which is secure, flexible and scalable.

Our Facility

The BioAscent Automated Compound Store has three individually housed, environmentally controlled -20°C stores for compound solutions, and a dedicated Kardex powder store. We can store compounds in a range of plate formats, 2D Matrix tubes and REMP Storage Microtube Technology.

Our advanced equipment ranges from workstations for automated solubilisation of samples, to full robotic systems which reformat and replicate plates in 96, 384 and 1536-well plate formats, in a dry and controlled atmosphere to avoid DMSO water capture and preserve the quality of the compound in solution.

Solubilized samples can be divided into multiple aliquots in individual REMP microtubes, each containing just the right volume for single use, and thawed once just before use in an assay. The microtubes are individually sealed and can be selected straight into a delivery rack when needed using the store’s rapid robotic cherry picking capability.

This means that cherry picking occurs within the environmentally controlled storage system, virtually eliminating the risk of sample degradation arising from multiple freeze/thaw cycles and providing the flexibility of random, rapid and individual selection and arrangement of only needed samples – when they are needed.

Using the single use tube storage technology reduces wastage of compounds, eliminates the need to store locally in sub-optimal conditions, and ensures the integrity and quality of the compounds being tested.

Our Systems for Securing your Collections

Our facility is constructed to provide the maximum protection possible for valuable collections, with a geographic location selected for its lack of extreme weather conditions and earthquakes. There is redundancy designed into the cooling systems, and extensive fire protection with the three REMP liquid stores, and Kardex powder store housed in four independent fire-protected enclosures, each fitted with fire extinguishing systems (Argonite/FE-13).

Our IT Infrastructure

In addition to secure off site backup provision, the IT infrastructure includes identical servers, located in separate buildings, fitted with fire protection and ventilation systems. Hardware and software are both designed to offer the maximum redundancy to avoid any interruption of operations.

We use Mosaic, from Titian, for our workflow management, inventory tracking and ordering system.

Mosaic is the most widely used software in sample management, giving full control of samples, managing the compound inventory, storage, processing and remote ordering.

Publications

  • MacKenzie S. and Boucharens S., (2014) Compound Interest. European Biopharmaceutical Review October 2014: 62-65.
  • Boucharens S., Warner A., (2012) Outsourcing Sample Management. Management of Chemical and Biological samples for screening application. Edited by Wigglesworth M. and Wood T. WILEY VCH Chapter 18 (ISBN: 978-3-527-32822-2)
  • Boucharens S., (2010) Outsourcing Compound Inventory: Trend or real Benefits. Pharmaceutical Outsourcing November/December 2010.

Get In Touch

Let's talk about how we can maximise your drug discovery success.

Contact

David Milroy

David is a Partner at Maven Capital Partners where he is a member of Maven’s Investment Committee and is responsible for sourcing and executing private equity investments in Scotland as well as technology and life science investments across the UK. His current investments include Blacktrace Group, Curo Compensation, Optoscribe, QikServe, CB Technology and BioAscent. David started his career as a scientist with GlaxoSmithKline.

After completing his PhD, he moved to international consultancy firm Wood Mackenzie (and then parent Deutsche Bank) where he supported the healthcare banking team, advising clients on their corporate and licensing strategies; and performing due diligence projects on companies, products and technologies.

David joined Aberdeen Asset Management’s private equity division (spun-out to form Maven in 2009) in September 2007 as Fund Manager for an early-stage technology fund. David has a First Class Honours degree in Pharmacy, a PhD (Molecular Biology/Gene Delivery) from the University of Bath and a MBA from The University of Edinburgh.

Director of Chemistry

Dr Angus Morrison

Angus has over 15 years’ experience as a practising medicinal chemist leading both project and medicinal chemistry delivery in multinational and multidisciplinary teams.  In his most recent role as Head of Chemistry at the European Screening Centre Newhouse he was Medicinal Chemistry lead of the European Lead Factory project responsible for over 30 hit to leads programmes.  Prior to this Angus has held leadership roles at Organon, Schering-Plough, MSD, Prosidion and Redx Oncology. During his time in pre-clinical drug discovery he has had broad exposure and experience of working across a diverse range of therapeutic areas and target classes from hit generation to candidate nomination.  Angus has a PhD in Organic Chemistry from Strathclyde University and carried out Postgraduate studies at Cambridge University. He is a co-author on over 30 papers and patents.

Director of Chemistry

Dr Angus Morrison

Angus has over 15 years’ experience as a practising medicinal chemist leading both project and medicinal chemistry delivery in multinational and multidisciplinary teams.  In his most recent role as Head of Chemistry at the European Screening Centre Newhouse he was Medicinal Chemistry lead of the European Lead Factory project responsible for over 30 hit to leads programmes.  Prior to this Angus has held leadership roles at Organon, Schering-Plough, MSD, Prosidion and Redx Oncology. During his time in pre-clinical drug discovery he has had broad exposure and experience of working across a diverse range of therapeutic areas and target classes from hit generation to candidate nomination.  Angus has a PhD in Organic Chemistry from Strathclyde University and carried out Postgraduate studies at Cambridge University. He is a co-author on over 30 papers and patents..

CEO BioCity

Dr Glenn Crocker MBE DPhil

Glenn Crocker is an experienced CEO, company founder, non-executive director and investor in the life sciences sector. He has been CEO of BioCity Group since mid-2003, shortly after it was founded. He has a DPhil in Immunology from Oxford University and qualified as a chartered accountant with EY, focussing on working with biotech companies in Palo Alto, California and Cambridge, UK, where he headed up the UK Biotech practice for EY.

BioCity builds, funds and grows life science companies at its four incubator sites in the UK.

Glenn is a non-executive director of a number of companies and consults on business incubation, start-up creation and cluster growth. He has been directly involved in investing in life science companies through BioCity’s own or managed funds since 2006.

In 2014 Glenn received an MBE for services to the biotechnology industry.

Dr Louis J. Nisbet D.Sc. - Vivanova Ltd

Dr Louis Nisbet

Louis began his career in pharmaceuticals R&D with Roche, Glaxo and SmithKline during which period he achieved international recognition in the discovery of NCEs in infectious diseases. He was one of the UK’s first biotechnology entrepreneurs establishing Xenova and Brax both of which achieved successful exits via IPO and trade sale respectively.

He was the first recipient of the Ernst & Young Biotechnology Entrepreneur of the Year Award. Since 2000 he has been active in investing and building businesses in the private and public equity markets across the health sector. Venture capital investments have been with Kurma Partners, Sitka Partners, Noble Group and Alderley Park Ventures.

He has considerable executive and non-executive Board experience with over 20 quoted and private companies. He has a Ph.D. from Imperial College, London and D.Sc. from the U of Strathclyde.

Chief Commercial Officer

Dr Mike Piper

Mike is an experienced life sciences professional with a track record in sales and marketing strategy, general management, licensing and contract negotiation.  Mike was formerly Head of Sales and Marketing at CXR Biosciences, an investigative toxicology CRO. Following CXR’s acquisition by Concept Life Sciences in 2015 he became Vice President Business Development Safety & Toxicology.  Prior to his time at CXR, Mike worked in business development and licensing at the specialty pharmaceutical company Ardana plc, and held various pharmaceutical industry management consultancy roles at ZS Associates, Deloitte and Arthur Andersen Business Consulting.  Mike has a PhD in genomics from the University of Cambridge, MRC Laboratory of Molecular Biology.

Chief Scientific Officer

Dr Phil Jones

Phil has over 30 years medicinal chemistry and drug discovery experience from Roche, Organon, Schering-Plough, Merck and the University of Dundee including senior roles as Executive Director and Acting Site Head. He was a member of the Research Leadership Council at Schering-Plough. Numerous clinical candidates resulted from groups for which he was responsible. These span a broad range of target families and therapeutic areas. He has led the European Screening Centre team at Biocity Scotland, Newhouse for the past 5 years and this group plays a key role in delivering validated hit series for SMEs and academics through the IMI funded European Lead Factory. Phil’s postgraduate studies were carried out at the University of Manchester and Imperial College. Phil was elected a Fellow of the Royal Society of Chemistry in 2005, he chaired the Medicinal Chemistry interest group of the Royal Society of Chemistry for 8 years, chaired the organising committee of the European Federation of Medicinal Chemistry – International Symposium on Medicinal Chemistry (EFMC-ISMC) in 2016 and sat on the Executive Committee of the EFMC for four years. He is a co-author on over 70 scientific papers and patents.

Chief Scientific Officer

Dr Phil Jones

Phil has over 30 years medicinal chemistry and drug discovery experience from Roche, Organon, Schering-Plough, Merck and the University of Dundee including senior roles as Executive Director and Acting Site Head. He was a member of the Research Leadership Council at Schering-Plough. Numerous clinical candidates resulted from groups for which he was responsible. These span a broad range of target families and therapeutic areas. He has led the European Screening Centre team at Biocity Scotland, Newhouse for the past 5 years and this group plays a key role in delivering validated hit series for SMEs and academics through the IMI funded European Lead Factory. Phil’s postgraduate studies were carried out at the University of Manchester and Imperial College. Phil was elected a Fellow of the Royal Society of Chemistry in 2005, he chaired the Medicinal Chemistry interest group of the Royal Society of Chemistry for 8 years, chaired the organising committee of the European Federation of Medicinal Chemistry – International Symposium on Medicinal Chemistry (EFMC-ISMC) in 2016 and sat on the Executive Committee of the EFMC for four years. He is a co-author on over 70 scientific papers and patents.

Director of Biosciences

Dr Stuart McElroy

With over 12 years working in drug discovery Stuart has extensive experience of developing and trouble-shooting novel screening assays, designing screening cascades, compound screening, hit validation and supporting hit to lead and lead optimisation programs. Throughout the 5 years of the European Lead Factory project he held the position of Head of Biology at the European Screening Centre (ESC), leading a team of bioscientists in prosecuting and triaging the output of over 90 high throughput screens across all major target classes and disease indications. Prior to this Stuart helped establish the Dundee Drug Discovery Unit (DDU) where he spent 7 years as a project and then team leader working across a wide array of novel drug targets and assays. He also had a leading operational role in DDU-Industry partnerships with both large pharma and SMEs.

Director of Biosciences

Dr Stuart McElroy

With over 12 years working in drug discovery Stuart has extensive experience of developing and trouble-shooting novel screening assays, designing screening cascades, compound screening, hit validation and supporting hit to lead and lead optimisation programs. Throughout the 5 years of the European Lead Factory project he held the position of Head of Biology at the European Screening Centre (ESC), leading a team of bioscientists in prosecuting and triaging the output of over 90 high throughput screens across all major target classes and disease indications. Prior to this Stuart helped establish the Dundee Drug Discovery Unit (DDU) where he spent 7 years as a project and then team leader working across a wide array of novel drug targets and assays. He also had a leading operational role in DDU-Industry partnerships with both large pharma and SMEs.

Chief Operating Officer and Co-founder

Dr Sylviane Boucharens

Sylviane has more than 20 years’ experience in scientific research and drug discovery environment. Sylviane has a track record in building and leading outstanding and productive teams into seamless successful enterprises in start-up and medium and large pharma environment. Prior to BioAscent Sylviane was Head of Global Compound repository and in-vitro Screening (Merck Sharp & Dohme, Newhouse Scotland). She was also responsible for managing a portfolio of early Drug Discovery projects in Cardiovascular from Target Identification and validation to Lead Optimisation. Sylviane attained her PhD in Cellular and Molecular Biology from the University Joseph Fourier, Grenoble, France, followed by post-doctoral positions at the INSERM U366 Laboratory, France and University of Manchester, UK under the Wellcome Trust International Fellowship.

Chief Operating Officer and Co-founder

Dr Sylviane Boucharens

Sylviane has more than 20 years’ experience in scientific research and drug discovery environment. Sylviane has a track record in building and leading outstanding and productive teams into seamless successful enterprises in start-up and medium and large pharma environment. Prior to BioAscent Sylviane was Head of Global Compound repository and in-vitro Screening (Merck Sharp & Dohme, Newhouse Scotland). She was also responsible for managing a portfolio of early Drug Discovery projects in Cardiovascular from Target Identification and validation to Lead Optimisation. Sylviane attained her PhD in Cellular and Molecular Biology from the University Joseph Fourier, Grenoble, France, followed by post-doctoral positions at the INSERM U366 Laboratory, France and University of Manchester, UK under the Wellcome Trust International Fellowship.

Chief Operating Officer and Co-founder

Dr Sylviane Boucharens

Sylviane has more than 20 years’ experience in scientific research and drug discovery environment. Sylviane has a track record in building and leading outstanding and productive teams into seamless successful enterprises in start-up and medium and large pharma environment. Prior to BioAscent Sylviane was Head of Global Compound repository and in-vitro Screening (Merck Sharp & Dohme, Newhouse Scotland). She was also responsible for managing a portfolio of early Drug Discovery projects in Cardiovascular from Target Identification and validation to Lead Optimisation. Sylviane attained her PhD in Cellular and Molecular Biology from the University Joseph Fourier, Grenoble, France, followed by post-doctoral positions at the INSERM U366 Laboratory, France and University of Manchester, UK under the Wellcome Trust International Fellowship.

Ian McDonald

Ian is a Chartered Accountant and an experienced Finance Director/Chief Financial Officer with a successful track record gained in SMEs and PLCs in the manufacturing and customer service industries - particularly within life sciences, pharmaceuticals and FMCG.  

Ian has successful record of achievement as a CFO within Private Equity backed businesses with credibility gained from developing positive and effective relationships with stakeholders, and successful participation in exits with a proven track record in securing funding for growth from both public sector finance providers as well as institutional finance providers. 

Ian’s career is varied having worked primarily in the UK but with extensive overseas travel. As well as heading up a number of large finance teams Ian’s experience extends to successfully evaluating  and commercially shaping high value projects including worldwide ERP system implementations as well as mergers and acquisition experience.

Chief Executive Officer

Paul Smith

An experienced Senior Executive with both General Management and Business Development experience in the pharmaceutical/CRO arena. Paul has an understanding of the drug development process from discovery to clinical research gained through more than 29 years in the CRO/pharmaceutical sector. A strategic thinker and management professional with experience gained in both small and large companies and with recent start-up experience including leading  funding discussions with VCs and other corporate finance groups. Paul recently turned around and sold CXR Biosciences to Concept Lifesciences in late 2015. Elected Fellow of the Royal Society of Biology, 2013.

Chief Executive Officer

Paul Smith

An experienced Senior Executive with both General Management and Business Development experience in the pharmaceutical/CRO arena. Paul has an understanding of the drug development process from discovery to clinical research gained through more than 29 years in the CRO/pharmaceutical sector. A strategic thinker and management professional with experience gained in both small and large companies and with recent start-up experience including leading  funding discussions with VCs and other corporate finance groups. Paul recently turned around and sold CXR Biosciences to Concept Lifesciences in late 2015. Elected Fellow of the Royal Society of Biology, 2013.