BioAscent's medicinal chemistry services are provided by our highly talented team of chemists. This team has extensive experience of prosecuting drug discovery programmes to success gained from within leading pharmaceutical and biotechnology companies. We understand the importance of making the right compound, not any compound, and that delivering a successful molecule with the appropriate biological, ADME and safety profile is set at the design stage.
Working in close partnership with you to understand your philosophies and project needs we can design and synthesise the optimal ligands for your project at all phases of the discovery process (Hit generation, Hit to Lead, Lead Optimisation). With our wealth of knowledge as drug hunters we can quickly and efficiently take your programme to success.
Our medicinal chemistry team has worked on a broad range of target and ligand classes including; Enzymes (Kinases, Proteases, Hydrolases, Dehydrogenases, Demethylases, DUBs), Ion Channels, GPCRs, Nuclear Receptors, Protein-Protein interactions and Allosteric modulators.
Our synthetic chemistry capabilities include multi-step synthesis of complex molecules, asymmetric synthesis, route design, building block synthesis, parallel synthesis of ligand arrays and reference molecules.
To support our talented team we have a comprehensive range of equipment, including:
Bruker Avance III 400 MHz NMR with multinuclear probe and 120-position carousel sample changer
Agilent 1200 and 1290 analytical LCMS systems with CTC autosamplers capable of both plate and vial-based sampling
Waters and Berger analytical/semi-prep SFC systems capable of achiral/chiral method development and separation with automated sample management
Waters fully automated semi-prep HPLC systems with diode array detection
Biotage Isolera automated purification systems with either dual wavelength or diode array detection
Genevac centrifuges with plate, vial and tube capability
Biotage Initiators with up to 60-sample capacity
Thales Nano H-Cube
Uniqsis Flowsyn Multi-X with high and low temperature capability
Extensive array of parallel synthesis equipment
ElectraSyn 2.0, Merck Photoreactor M1
In an industry standard, secure Dotmatics database
Posters & case studies