The team at BioAscent has leading expertise in GPCR drug discovery. Our capabilities encompass assay development, optimisation, and screening using all major label-based and label-free GPCR assay technologies; medicinal chemistry; in-silico / computational chemistry approaches; and fully integrated GPCR drug discovery projects.
With wide-ranging background from big pharma, biotech and academia, our team has a median drug discovery experience of 15 years. Currently, almost 50% of the target portfolio are GPCR projects, encompassing bespoke lead characterisation projects, through to fully integrated multi-FTE, hit-to-lead and lead optimisation programmes.
Learn more about our biosciences services here.
The BioAscent biosciences team worked as independent contributors, suggesting and successfully developing assays for a novel GPCR target, and deploying these to support rapid design-make-test cycles. As well supplying assays and data of extremely high quality, the initiative the BioAscent team showed when designing and interpreting experiments was a critical factor in the success of this project. Ours was very much a team of intellectual equals, and this intellectual collaboration was very much a driving force behind the success of this programme.
Head of GPCR Pharmacology, Biotech
Our project, against a novel GPCR target, has been a career highlight. We’ve worked closely with BioAscent from the initial assay development and screen, through hit confirmation, hit-to-lead and lead-optimisation, to the point where we have two preclinical candidates. We asked BioAscent to make some really challenging compounds to support our SAR hypotheses, and without the expertise, initiative and tenacity of the BioAscent chemistry team, this project would not have succeeded. In summary, BioAscent has been the best chemistry CRO I’ve worked with.
Director, Medicinal Chemistry, Biotech
A validated hit is just the beginning of the story. At BioAscent, biosciences, chemistry, computational chemistry and compound management work as one team, so your design-make-test cycles don’t stall. The BioAscent team represents your one partner from assay to candidate. We are your fully-integrated service for GPCR programmes and beyond.
BioAscent scientists have extensive drug discovery expertise, utilising a wide range of technologies to design robust assays and deliver confident hit identification and mechanistic insights to accelerate decision making. With a proven track record from target validation through to candidate optimisation, BioAscent provides a uniquely comprehensive, flexible, and science led approach to even the most challenging targets.
