In the fast-paced world of early drug discovery efficiency is key. BioAscent chemists focus on synthesising the right compounds for our clients, from idea to delivery of high-quality material, quickly and effectively. Our teams have access to state-of-the-art tools, automation and laboratory equipment to realise this. We leverage in-house workflows to achieve rapid analogue synthesis and generation of SAR to drive projects forward, while co-location of our chemistry, biosciences and compound management teams on one site ensures swift turnaround times from synthesis to data.

Designed for modularity

Experts in synthetic chemistry, our scientists design synthetic strategies with a focus on selecting a convergent route, allowing many analogues to be prepared from common intermediates.

• Access to Reaxys chemical search engine facilitates the selection of practical, literature-backed synthetic routes with a high chance of success.

• ChemInventory software searches an in-house inventory of over 9000 commercial compounds, providing immediate access to diverse building blocks for analogue synthesis.

Parallelisation and automation

• In-house access to parallel chemistry equipment, pool and split cross-coupling optimisation kits, and catalyst screening kits.

• Rapid library purification is enabled by BioAscent’s automated mass-directed HPLC systems.

• Each final compound is fully characterised and meets our meticulous QC standards.

Informatics for efficiency

• Experimental results are recorded in state-of-the-art Dotmatics ELN providing a searchable, audit-ready record of chemistry procedures and experimental outcomes.

• Dotmatics ELN data provides a curated library of validated reaction conditions and can be mined in-house to predict likelihood of reaction success based on previous experiments.

Integrated drug discovery services facilitate rapid turnaround

• Efficient integrated workflows result in fast turnaround times.

• BioAscent’s extensive compound management capabilities can be integrated into projects to provide seamless weighing, dissolution, plating and shipping of compounds.

• Our in-house biosciences experts provide optional assay and screening support, seamlessly integrated into project workflows.

BioAscent’s fast-track chemistry workflows accelerate high-quality compound synthesis and SAR generation for early drug discovery. Expert teams, advanced automation, and integrated services ensure rapid turnaround from design to data.

To learn more about how our chemistry team can add value to your projects, contact us.